Figure 4.

Cannabinoid treatment inhibits both virus and myelin autoimmune inflammatory DTH responses. Treatment of mice with R(+)WIN55,212 (black bars) at the time of TMEV infection (a), at the onset of clinical disease (b), or during established disease (c), significantly reduces DTH responses to rechallenge with either the immunodominant TMEV peptide VP2_70-86 or the autoreactive myelin PLP_139-151 peptide. *Significant reduced DTH responses compared with either S(–)WIN55,212 (dark gray bars) or untreated TMEV-infected (white bars) mice (P < 0.05). Naive mice (light gray bars) show a low background response to either peptide.