Figure 5.

Cannabinoid receptor agonism inhibits Th1-mediated IFN-γ cell secretion. Treatment with R(+)WIN55,212 at the time of infection (a) or at the onset of clinical disease (b) significantly inhibited IFN-γ secretion from T lymphocytes rechallenged with either VP2_70-86 or PLP_139-151 compared with either S(–)WIN55,212 (gray bars) or untreated TMEV-infected mice (white bars). R(+)WIN55,212 treatment during established disease (c) had no significant effect on IFN-γ secretion. *Cytokine response was significantly inhibited compared with either S(–)WIN55,212 or untreated TMEV-infected mice. P < 0.05.