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. 2003 Apr 15;111(8):1231–1240. doi: 10.1172/JCI17652

Figure 6.

Figure 6

Cannabinoid treatment inhibits mRNA coding for both antiviral and Th1- and Th2-type inflammatory mediators in the CNS. R(+)WIN55,212 treatment at the time of infection (day 0–5) inhibited spinal cord mRNA coding for the innate antiviral mediators, IFN-α, and IFN-β (a). R(+)WIN55,212 treatment at the onset of disease inhibited spinal cord mRNA coding for the proinflammatory Th1 mediators, IL-1β, IL-6, TNF-α, and IFN-γ, but not the IL-12 p40 subunit (b). Treatment at disease onset also inhibited mRNA coding for the Th2 cytokine IL-4, but not IL-10 (c). The mRNA levels are presented as the percentage of intensity of the HPRT control for that sample.