Table 2.
Comparison of Salmonella Iro proteins with E. coli Iro proteins and proteins involved in microcin biosynthesis
| iro gene from Salmonella | Homologs | Size of gene product, aa | Putative or demonstrated* function of the proteins | % Amino acid identity |
|---|---|---|---|---|
| iroB | 371 | Glycosyltransferase | ||
| iroB E. coli 536 | 371 | Glycosyltransferase | 72 | |
| mceC Klebsiella pneumoniae | 370 | Maturation of microcin E492 | 77 | |
| mcmL E. coli | 372 | Maturation of microcins M and H | 72 | |
| snoG Streptomyces nogalater | 390 | Glycosyltransferase* | 33 | |
| iroC | 1,261 | ABC exporter | ||
| iroC E. coli 536 | 1,218 | ABC exporter | 76 | |
| SCO2763 Streptomyces coelicolor | 1,243 | ABC transporter | 39 | |
| MDR1 Homo sapiens | 1,280 | ABC exporter, multidrug resistance protein 1* | 28 | |
| iroD | 409 | Similar to enterochelin esterase | ||
| iroD E. coli 536 | 414 | Similar to enterochelin esterase | 68 | |
| mceD K. pneumoniae | 414 | Maturation of microcin E492 | 56 | |
| mcmK E. coli | 424 | Maturation of microcins M and H | 55 | |
| fes E. coli | 374 | Enterochelin esterase* | 27 | |
| iroE | 318 | Periplasmic hydrolase | ||
| iroE E. coli 536 | 311 | Periplasmic hydrolase | 61 | |
| AMY3E Oryza sativa | 437 | Alpha-amylase isozyme 3E* | 26 | |
| iroN | 725 | Catecholate siderophore receptor* | ||
| iroN E. coli 536 | 726 | Catecholate siderophore receptor* | 82 | |
| fepA E. coli | 746 | Enterochelin receptor* | 52 | |
| cir E. coli | 663 | DHBS-catecholate siderophore receptor* | 33 | |
| fiu E. coli | 760 | DHBS-catecholate siderophore receptor* | 22 |
The similarity to some better-defined homologs and the percent identity are given.
*
Proteins for which experimental evidence for the function is available.