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. 2003 Apr;14(4):1334–1345. doi: 10.1091/mbc.E02-07-0378

Figure 9.

Figure 9

Effect of CD40 ligation and NF-κB inhibition on IHEC proliferation. (A) Histogram shows the proliferative index expressed as the percentage of Ki67-positive cells up to 72 h for either unstimulated IHECs or after CD40 stimulation (n = 8). CD40 stimulation led to a marked increase in cell proliferation in the endothelial cells. (B) Histogram shows the proliferative index expressed as the percentage of Ki67-positive cells for unstimulated IHECs or cells stimulated via CD40 in the presence or absence of the specific and potent NF-κB inhibitor, CAPE (25 μg/ml). The addition of CAPE completely inhibited the endothelial cell proliferation in response to CD40 activation. The results represent data from at least three separate experiments.