Table 3.
Validity Estimates of PGI/PGII Serum Level Ratio [% (CI 95%)] Either Alone or Considering H. pylori Infection as Risk Factor for the Diagnosis of Lesions as Severe as Extensive Incomplete IM, Dysplasia, or HGD and Its Variation After (n = 136).
| Diagnosis | Positive Test Defined as PGI/PGII Serum Level Ratio | Positive Test Defined as Either H. pylori Infection-Detected or PGI/PGII Serum Level Ratio | ||||
| ≤4 | ≤3 | ≤2 | ≤4 | ≤3 | ≤2 | |
| Extensive IM (n = 61) | ||||||
| Sensitivity | 80% (73–87) | 66% (57–74) | 36% (28–44) | 84% (78–90) | 74% (66–81) | 59% (51–67) |
| 49/61 | 40/61 | 22/61 | 51/61 | 46/61 | 36/51 | |
| Specificity | 60% (51–68) | 78% (71–85) | 82% (75–89) | 39% (31–47) | 46% (37–55) | 46% (37–55) |
| 44/74 | 58/74 | 61/74 | 29/74 | 34/74 | 34/74 | |
| Positive predictive value | 62% (54–70) | 66% (58–74) | 63% (55–71) | 53% (44–61) | 54% (45–63) | 47% (38–56) |
| 49/79 | 40/56 | 22/35 | 51/96 | 46/86 | 36/76 | |
| Negative predictive value | 78% (71–85) | 73% (65–81) | 61% (53–69) | 74% (66–82) | 69% (61–77) | 58% (49–66) |
| 44/56 | 58/79 | 61/100 | 29/39 | 34/49 | 34/59 | |
| Likelihood ratio of a positive test | 1.98 (1.74–2.21) | 3.00 (2.56–3.42) | 2.00 (1.76–2.24) | 1.38 (1.25–1.50) | 1.37 (1.25–1.49) | 1.09 (1.04–1.14) |
| Likelihood ratio of a negative test | 0.34 (0.26–0.42) | 0.44 (0.35–0.52) | 0.78 (0.71–0.85) | 0.41 (0.32–0.49) | 0.56 (0.48–0.65) | 0.89 (0.84–0.94) |
| Dysplasia (n = 23) | ||||||
| Sensitivity | 78% (71–85) | 70% (62–78) | 57% (49–65) | 83% (77–89) | 74% (66–82) | 65% (57–73) |
| 18/23 | 16/23 | 13/23 | 19/23 | 17/23 | 15/23 | |
| Specificity | 46% (37–54) | 65% (57–73) | 81% (74–88) | 31% (23–39) | 38% (30–46) | 46% (37–55) |
| 51/112 | 72/112 | 90/112 | 35/112 | 43/112 | 51/112 | |
| Positive predictive value | 23% (16–30) | 29% (21–36) | 37% (29–45) | 20% (13–27) | 20% (13–27) | 20% (13–27) |
| 18/79 | 16/56 | 13/35 | 19/96 | 17/86 | 15/76 | |
| Negative predictive value | 91% (86–96) | 91% (86–96) | 90% (85–95) | 90% (85–95) | 88% (82–94) | 86% (80–92) |
| 51/56 | 72/79 | 90/100 | 35/39 | 43/49 | 51/59 | |
| Likelihood ratio of a positive test | 1.44 (1.31–1.58) | 2.00 (1.76–2.24) | 3.00 (2.58–3.42) | 1.20 (1.12–1.29) | 1.19 (1.11–1.28) | 1.20 (1.12–1.29) |
| Likelihood ratio of a negative test | 0.48 (0.39–0.56) | 0.46 (0.38–0.55) | 0.53 (0.45–0.62) | 0.55 (0.46–0.63) | 0.68 (0.60–0.76) | 0.76 (0.69–0.84) |
| HGD (n = 11) | ||||||
| Sensitivity | 91% (86–96) | 82% (75–89) | 73% (65–81) | 90% (85–95) | 82% (75–89) | 73% (65–81) |
| 10/11 | 9/11 | 8/11 | 10/11 | 9/11 | 8/11 | |
| Specificity | 45% (36–54) | 63% (55–71) | 79% (72–86) | 31% (23–39) | 38% (30–46) | 45% (36–54) |
| 55/124 | 77/124 | 97/124 | 38/124 | 47/124 | 56/124 | |
| Positive predictive value | 13% (7–19) | 16% (10–22) | 22% (15–29) | 10% (5–15) | 11% (6–16) | 11% (6–16) |
| 10/79 | 9/56 | 8/35 | 10/96 | 9/86 | 8/76 | |
| Negative predictive value | 98% (96–100) | 98% (96–100) | 97% (94–99) | 97% (94–99) | 96% (93–99) | 95% (91–99) |
| 55/56 | 77/79 | 97/100 | 38/39 | 47/49 | 56/59 | |
| Likelihood ratio of a positive test | 1.65 (1.48–1.83) | 2.22 (1.93–2.50) | 3.48 (2.97–3.98) | 1.30 (1.20–1.41) | 1.32 (1.21–1.43) | 1.33 (1.21–1.44) |
| Likelihood ratio of a negative test | 0.20 (0.13–0.27) | 0.28 (0.21–0.36) | 0.34 (0.26–0.42) | 0.32 (0.24–0.40) | 0.47 (0.39–0.56) | 0.60 (0.52–0.68) |