Table 6.
Tissue Accumulation of DB67 After Its Injection in Free or Liposomal Form.
| Treatment | Time (hours) |
Percent Injected Dose Per Gram of Tissue | |||
| Spleen | Liver | ||||
| i.p. | i.v. | i.p. | i.v. | ||
| DB67 | 0.5 | 1.95 ± 0.43 | - | 11.02 ± 1.05 | - |
| 2 | 0.69 ± 0.10 | - | 4.80 ± 1.27 | - | |
| Lipo-DB67 | 0.5 | 2.21 ± 0.33 | 3.50 ± 0.45 | 12.01 ± 1.27 | 15.98 ± 1.00 |
| 2 | 0.23 ± 0.03 | 0.23 ± 0.05 | 4.80 ± 0.42 | 4.60 ± 0.45 | |
In both cases, DB67 was injected intraperitoneally or intravenously as a single bolus of 7 mg/kg. Balb/c mice were sacrificed at indicated time points after injection. Tissue samples were collected and analysed for drug content (see Materials and Methods section). The values are expressed as percentage of the injected dose ±SD per gram of tissue of five mice per group.