Table 1.

Key Cytokine and Chemokine Changes (pg/ml) in the Tumor Microenvironment and in the Serum of Small Tumor-Bearing Mice Following Treatment with Either Control ODN or CpG ODN.

		Control Mice	CpG-Treated Mice	Fold Increase	P
IL-6	Intratumor	69 ± 46	2807 ± 1836	40	0.02
	Serum	3 ± 3	24 ± 6	8	0.008
GM-CSF	Intratumor	3.5 ± 0.57	46.75 ± 32.3	13	0.03
	Serum	0	0	nd
CXCL1	Intratumor	38 ± 31	3379 ± 1436	88	0.02
	Serum	12 ± 10	86 ± 68	7	0.07
CCL2	Intratumor	560 ± 413	8962 ± 3344	16	0.002
	Serum	71 ± 22	159 ± 38	2	0.009
CCL3	Intratumor	988 ± 114	2343 ± 974	2	0.03
	Serum	543 ± 370	1050 ± 246	1.9	0.09
CCL5	Intratumor	917 ± 393	1709 ± 565	1.8	0.06
	Serum	0	70 ± 8	nd

nd, not determined.