Table 3.
Selected Genes Whose Expression Is Downregulated in Mouse Bladder Tumors Compared with Normal Bladder Epithelia Identified by Microarray.
| Downregulated Genes in Mouse Bladder Tumors Identified by Microarray | |||||||||
| Gene | Access | Description | Fold Change* | Incidence | |||||
| Cell cycle-related genes | |||||||||
| Ccng1 | L49507 | Cyclin G1 | 2.0 | 3/5 | |||||
| Gas1 | X65128 | Growth arrest-specific 1 | 2.8 | 4/5 | |||||
| Madh2 | U60530 | MAD homolog 2 | 2.9 | 5/5 | |||||
| Atm | U43678 | Ataxia telangiectasia-mutated homolog | 4.9 | 5/5 | |||||
| Rbbp7 | U35142 | Retinoblastoma - binding protein 7 | 2.1 | 3/5 | |||||
| Rbl2 | U36799 | Retinoblastoma-like 2 | 2.0 | 3/5 | |||||
| Ras pathway effectors | |||||||||
| Rab11a | AI853996 | RAB11a, member of RAS oncogene family | 2.5 | 3/5 | |||||
| Rab33b | AW208630 | RAB33B, member of RAS oncogene family | 2.6 | 5/5 | |||||
| Rab3d | AI835706 | RAB3D, member of RAS oncogene family | 2.1 | 4/5 | |||||
| Rab9 | AB027290 | RAB9, member of RAS oncogene family | 2.1 | 5/5 | |||||
| Arhgdia | AI836322 | Rho GDP dissociation inhibitor (GDI) α | 7.0 | 5/5 | |||||
| Arhgdig | U73198 | Rho GDP dissociation inhibitor (GDI) gamma | 2.8 | 4/5 | |||||
| Rhob | X99963 | rhoB gene | 2.1 | 4/5 | |||||
| Arhq | D50264 | Ras homolog gene family, member Q | 2.6 | 4/5 | |||||
| Transcription regulators | Tbx2 | U15566 | T-box 2 | 4.0 | 5/5 | ||||
| Ndr2 | AB033921 | N-myc downstream-regulated 2 | 21.1 | 5/5 | |||||
| Lasp1 | AW122780 | LIM and SH3 protein 1 | 2.3 | 4/5 | |||||
| Lmo1 | AW124311 | LIM domain only 1 | 6.5 | 5/5 | |||||
| Lmo4 | AF074600 | LIM domain only 4 | 2.3 | 4/5 | |||||
| Pdlim3 | AF002283 | PDZ and LIM domain 3 | 4.9 | 5/5 | |||||
| Tcf2 | AB008174 | Transcription factor 2 | 2.0 | 3/5 | |||||
| Tcf21 | AF035717 | Transcription factor 21 | 3.7 | 4/5 | |||||
| Tcf3 | AJ223069 | Transcription factor 3 | 2.5 | 3/5 | |||||
| Gata2 | AB000096 | GATA-binding protein 2 | 3.5 | 5/5 | |||||
| Gata3 | X55123 | GATA-binding protein 3 | 9.2 | 5/5 | |||||
| Gata4 | M98339 | GATA-binding protein 4 | 2.3 | 3/5 | |||||
| Cri1 | AI844939 | CREBBP/EP300-inhibitory protein 1 | 2.3 | 5/5 | |||||
| MAPK/Src homolog | |||||||||
| Erk2 | D87271 | ERK2 | 2.6 | 4/5 | |||||
| Map2k6 | U39066 | Mitogen-activated protein kinase kinase 6 | 2.5 | 3/5 | |||||
| Map3k4 | AV270901 | Mitogen-activated protein kinase kinase kinase 4 | 3.0 | 4/5 | |||||
| Map3k5 | AB006787 | Mitogen-activated protein kinase kinase kinase 5 | 2.5 | 4/5 | |||||
| Map3k8 | AV341985 | Mitogen-activated protein kinase kinase kinase 8 | 3.0 | 3/5 | |||||
| Sh2bpsm1 | AF020526 | SH2-B PH domain containing signaling mediator 1 | 2.1 | 3/5 | |||||
| Sh3bgr | AW048272 | SH3-binding domain, glutamic acid-rich protein | 4.9 | 5/5 | |||||
| Sh3bp1 | X87671 | SH3 domain-binding protein 1 | 2.8 | 4/5 | |||||
| Sh3gl2 | U58886 | SH3 domain GRB2-like 2 | 13.0 | 5/5 | |||||
| Sh3gl3 | U58887 | SH3 domain GRB2-like 3 | 2.5 | 4/5 | |||||
Downregulated genes include the mitogen-activated protein kinase genes, cell cycle checkpoint genes, Rab subfamily genes, Rho subfamily genes, and SH2 and SH3 domains-related genes.
*
Fold change is the ratio of mean gene expression values of the tumors to the mean gene expression values of the epithelia from the microarray.