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. 2004 Nov;6(6):705–712. doi: 10.1593/neo.04271

Figure 3.

Figure 3

Induction of early-stage apoptosis by TK inhibitors in malignant mesothelioma cells. The apoptosis was determined by Annexin-V FITC and PI staining and analyzed by flow cytometry. Histograms of cells versus log fluorescence intensity were generated. Shaded histograms represent fluorescence of cells treated with TGF-α only; open histograms indicate fluorescence of cells treated with different drugs and TGF-α. The early stage of apoptosis was observed in 14%, 28%, and 30% of the ZL34 cells treated with 10 µM of ZD1839, OSI-774, and CI-1033, respectively. Data shown are representative of three independent experiments. For each sample, 10,000 cells were analyzed.