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(A–C) Inhibition of MMP-9 production by TK inhibitors in malignant mesothelioma cells. The gels show proteolytic activity in serum-free conditioned medium in the presence or absence of different drugs and/or TGF-α. Bars summarize the relative activity of the area and intensity of MMP-9 and MMP-2, as determined by image analysis, with 0 ng/ml of TGF-α and 0 µM of drugs of MMP-9 band set as 1. Data shown are representative of three independent experiments.
