Figure 5.

Effects on angiogenesis in vitro (A) and in vivo (B). Infection of HUVEC at an MOI of 0.1 significantly suppressed in vitro tube-like formation (P < .001), whereas the effects were not observed after treatment with acyclovir (20 µM) or infection with G207 inactivated by UVB (A). G207 significantly prevented the formation of perfused vessels in the in vivo Matrigel plug assay (P < .001). In contrast, similar numbers of perfused vessels were observed in Matrigel plugs after mock infection or infection with UVB-irradiated G207 (B).