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. 2004 Nov;6(6):802–812. doi: 10.1593/neo.04247

Figure 5.

Figure 5

8-Cl-Ado-induced chromosome segregation failure. Cells were unexposed or exposed to 8-Cl-Ado (2 µM) for 24 to 96 hours. Immunocytochemistry was performed as described in Materials and Methods section. The cells were examined with confocal microscope. (A) Photographs characteristic of mitotic division of A549 cells unexposed (a–c) (control) or exposed to 8-Cl-Ado (d–f). Tubulin is labeled with green, actin with red, and DNA with blue. (B) Histograms showing the percentage of failed mitotic cells relative to the total mitotic cells in A549 and H1299 cells, respectively. Data represent mean ± SD derived from three independent experiments.