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Treatment with VT1 leads to a proapoptotic effect. TUNEL staining of IOMM-Lee tumours treated with VT1 (51±0.04%) shows a remarkable increase in the number of cells undergoing apoptosis. This is contrasted with the apoptotic indices of HI-VT-treated (2.6±0.009%, P<.0001) and PBS-treated (4.3± 0.012%, P<.0001) animals. There was no statistical significance between the levels of apoptosis in HI-VT- and PBS-treated animals (P<.6254).
