Table 1.

Nf1 Mouse Models.

Genotype	Phenotype	Reference
Nf1-/-	Embryonic lethality Double outlet right ventricle Exencephaly	[61–64]
Nf1+/-	Tumor development: pheochromocytoma, leukemia, lymphoma	[62]
	Astrogliosis; increased astrocyte proliferation	[75,76]
	Impaired spatial learning and memory	[80,81]
Neuronal Nf1 conditional knockout	Astrogliosis, growth retardation	[86]
Astrocyte Nf1 conditional knockout	Increased astrocyte proliferation	Bajenaru et al., unpublished results Zhu et al., unpublished results
Nf1 exon 23a knockout	Impaired spatial learning and contextual discrimination, delayed motor skill acquisition	[85]
Nf1-/- chimera	Plexiform neurofibromas, myelodysplasia, neuromotor defects	[82]
Nf1+/-: p53+/-	Malignant peripheral nerve sheath tumors	[82,83]
	Malignant astrocytomas	[84]