Table 2.

Nf2 Mouse Models.

Genotype	Phenotype	Reference
Nf2-/-	Embryonic lethality	[88]
Nf2+/-	Tumor development: osteogenic tumors, fibrosarcoma, liver tumors	[60,92]
P0-Sch-Δ(39–121) transgenic mice	Schwann cell hyperplasia, Schwann cell tumors (schwannoma, malignant peripheral nerve sheath tumors)	[87]
Schwann cell Nf2 conditional knockout	Schwann cell hyperplasia, Schwann cell tumors (schwannoma, malignant peripheral nerve sheath tumors)	[92]
Leptomeningeal cell Nf2 conditional knockout	Meningioma	[107]
Schwann cell Nf2 conditional knockout; Nf1+/-	Schwann cell hyperplasia, Schwann cell tumors (schwannoma, neurofibroma, malignant peripheral nerve sheath tumors)	Niwa-Kawakita et al., unpublished results, 2002