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Four-factor model of thymidine utilization (adapted from Ref. [35]). The chemical species entering and leaving the precursor pool are shown. Abbreviations in parentheses refer to enzymes at control points in the model: TS: thymidylate synthetase; TP: thymidine phosphorylase; TK: thymidine kinase. The line following the exogenous pathway into DNA indicates exogenous thymidine flux measured by labeled thymidine.
