Figure 1.

(A) The correlation between GdDTPA-uptake rates (k) and the perfused vascular surface-areas (S) in voxels of 10 9L-gliomas. The solid line indicates the results of the least-squares linear regression analysis of the data: k = 0.23 ± 0.02 SDxS, R² = 0.72 (n = 86). (B) Surface-plot of correlations between the PS-product (x-axis), TBP (y-axis) and GdDTPA-uptake rate constants (k) (z-axis) using the definition of the rate constant k as proposed by Kety [27] or Larsson et al. [28]. Note that the range of k-values is comparable to the range in (Figure 2A). These data are from work performed by B vander Sanden with grateful acknowledgements to Dr. T.H. Rozijn, Dr. W.M.M.J. Bovee, P.F.J.W. Rijken, Prof. A.J. van der Kogel and Prof. A. Heerschap.