TABLE 1.
Classification of SIR2-related genes
| Gene name | NCBI LocusLink IDa | Human chromosomal location | Protein product(s), conceptual translation | PSORT protein predictions (results of the k-NN prediction)b | Comments |
|---|---|---|---|---|---|
| SIRT1 | 23411 | 10q21.3 | Isoform 1 (747 aa), isoform 2 (555 aa) | SIRT1 (747 aa): 69.9% nuclear, 13.0% mitochondrial, 8.7% plasma membrane, 4.3% vesicles of secretory system, 4.3% cytoplasmic | Known as Sir1α in mice; ortholog of the Drosophila SIRT gene located at 34A7-8; ortholog of the C. elegans SIRT gene found on chromosome IV; probable ortholog identified in zebrafish as ESTc |
| SIRT2 | 22933 | 19q13.1 | Isoform 1 (389 aa), isoform 2 (352 aa) | SIRT2 (352 aa): 30.4% cytoplasmic, 21.7% mitochondrial, 17.4% extracellular (including cell wall), 17.4% nuclear, 4.3% cytoskeletal, 4.3% vacuolar, 4.3% endoplasmic reticulum | Known as SIR2L2 in mice ortholog of the Drosophila SIRT gene found on 3R92E; no apparent ortholog in C. elegans |
| SIRT3 | 23410 | 11p15.5 | Isoform A, (257 aa), isoform B (346 aa) | SIRT3 (399 aa): 44.4% endoplasmic reticulum, 22.2% Golgi, 11.1% mitochondrial, 11.1% nuclear, 11.1% cytoplasmic | Known as SIR2L3 in mice; no apparent ortholog in Drosophila or C. elegans |
| SIRT4 | 23409 | 12q | 314 aa | SIRT4 (314 aa): 33.3% endoplasmic reticulum, 22.2% vacuolar, 22.2% plasma membrane, 11.1% Golgi, 11.1% mitochondrial | Drosophila ortholog found at 65E5-6 on chromosome 3; in C. elegans there are 2 closely linked apparent orthologs on chromosome |
| SIRT5 | 23408 | 6pter-p25.1 | Isoform 1 (310 aa), isoform 2 (299 aa) | SIRT5 (310 aa): 65.2% mitochondrial, 8.7% cytoplasmic, 8.7% nuclear, 4.3% vacuolar, 4.3% extracellular (including cell wall) 4.3% plasma membrane, 4.3% peroxisomal | No apparent orthologs in either Drosophila or C. elegans |
| SIRT6 | 51548 | 19p13.3 | Isoform 1 (355 aa), isoform 2 (237 aa) | SIRT6 (355 aa): 78.3% nuclear, 13.0% cytoskeletal, 4.3% Golgi, 4.3% mitochondrial | Drosophila ortholog found at 3R 85F-86A; apparent C. elegans ortholog found on chromosome I |
| SIRT7 | 51547 | 17q25 | 400 aa | SIRT7 (400 aa): 56.5% nuclear, 26.1% cytoplasmic, 13.0% mitochondrial, 4.3% cytoskeletal | No apparent orthologs in either Drosophila or C. elegans |
a
LocusLink ID is available from the electronic repository at the National Center for Biolotechnology Information (NCBI), available at http://www.ncbi.nlm.nih.gov/LocusLink.
b
PSORT prediction is a summation of results of the k-nearest neighbor (k-NN) prediction according to the predictive software accessible at http://psort.nibb.ac.jp/form2.html.
c
EST, expressed sequence tag.