FIG. 1.

Alignment of amino acid sequences of C. elegans cystatin 1 (Cysele1), C. elegans cystatin 2 (Cysele2), A. viteae cystatin (Av17), onchocystatin (Ov17), and human cystatin C. The first amino acid of each sequence is the proposed N terminus of the mature protein. Similar amino acids are marked by dots, and identical amino acids are marked by asterisks. The evolutionarily conserved papain binding sites are boxed. The conserved asparaginyl endopeptidase (AEP) inhibitory domain is boxed with a dashed line. The sequence data are available from GenBank under the following accession numbers: Av17, L43053; Ov17, M37105; Cysele1, AJ310669; Cysele2, AJ310670; and human cystatin C, AAA52164.