TABLE 1.
Comparison of antibody responses in mice orally immunized with different amounts of EcMSP4/5 with or without 10 μg of CTB
| Antigen (μg) | No. of mice tested | Level (mean ± SD OD) of antibodies to:
|
|
|---|---|---|---|
| PyMSP4/5a | CTBb | ||
| CTB (10) | 8 | 0.002 ± 0.003 | 0.686 ± 0.366 |
| EcMSP4/5 (25) | 6 | 1.195 ± 0.514 | 0.005 ± 0.006 |
| EcMSP4/5 (25) + CTB (10) | 7 | 1.539 ± 0.510 | 0.771 ± 0.323 |
| EcMSP4/5 (5) + CTB (10) | 4 | 0.704 ± 0.751 | 0.665 ± 0.311 |
| EcMSP4/5 (1) + CTB (10) | 4 | 0.527 ± 0.406 | 0.680 ± 0.439 |
| EcMSP4/5 (0.2) + CTB (10) | 4 | 0.173 ± 0.342 | 0.705 ± 0.613 |
a
PyMSP4/5-specific antibodies were measured against EcMSP4/5 at a serum dilution of 1:10,000.
b
CTB-specific antibodies were measured against CTB at a serum dilution of 1:10,000.