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. 2003 May;71(5):2430–2438. doi: 10.1128/IAI.71.5.2430-2438.2003

FIG. 4.

FIG. 4.

Neutralization of IL-9 does not affect jejunal muscle contraction or worm expulsion in T. spiralis infection. (a) Carbachol-induced maximum tension generated by jejunal muscle strips after neutralization of IL-9 activity. Mice were infected with T. spiralis and treated with anti-IL-9 monoclonal antibody or with mouse IgG (1 mg on day 0 and then 0.5 mg on every alternate day until day 20 p.i.). Mice were killed at days 14 and 21 p.i. to investigate jejunal muscle contraction. Day 0 shows data for control noninfected mice. (b) Worm recovery from T. spiralis-infected mice following neutralization of IL-9 by anti-IL-9 vaccination or by anti-IL-9 antibody. Mice were immunized with IL-9- OVA or treated with anti-IL-9 antibody and then infected with T. spiralis. Mice were killed on day 21 p.i. to investigate intestinal worm burden. Values are means and SEMs for five animals.