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. 2003 May;71(5):2548–2554. doi: 10.1128/IAI.71.5.2548-2554.2003

FIG. 3.

FIG. 3.

(A) Alignment of the tetraspanin family members, bovine CD9, and human CD63 with the ORFs from S. mansoni clones p43F4 and p64A3, identified by AP-PST. Black boxes denote identical amino acids; gray boxes indicate similarity. Transmembrane domains TM-1 to TM-3 are marked by a line spanning the region in reference to the CD9 sequence. (B) Schematic arrangement of domains in tetraspanin family members. EC, extracellular loop; CT, cytoplasmic tail. (C) Alignment of the regions spanning the ligand binding domains (extracellular loop 2) of clones Sm-TSP-1 (corresponds to clone p64A3), Sm-TSP-2 (corresponds to p43F4), and other tetraspanin family members. Lines denote the known (CD81) and putative (all other sequences) disulfide bond linkages.