Representative Western blot of soluble fibrinogen products from sham controls, CLP plus irrelevant antibody (CLP), and CLP plus IFN-γ antibody (CLP + IFN-γ Ab) 12 h after surgery. Authentic fibrinogen (CON) was approximately 200 kDa in size. Densitometric analysis showed that CLP rats given IFN-γ antibody had more fibrinogen products larger than 200 kDa as well as products smaller than 200 kDa than those from CLP rats given irrelevant antibody. Values are means ± SEM. *, P < 0.05 compared to that for sham controls; #, P < 0.05 compared to that for CLP. For sham controls, n = 4; for CLP, n = 6; and for CLP + IFN-γ Ab, n = 6.