TABLE 3.

ORFs within islands of S. flexneri 2457T categorized by function

Functional category	No. of ORFs	Species with homologs
Virulence	10	S. flexneri, Y. pestis
Adhesin	7	S. enterica serovar Typhimurium, other pathogenic E. coli, A. actinomycetemcomitans
Regulatory	5	E. coli O157:H7, S. enterica serovar Typhi, other pathogenic E. coli
Energy metabolism	31	other pathogenic E. coli, E. coli O157:H7, S. enterica serovar Typhimurium, C. crescentus, L. monocytogenes, S. enterica serovar Typhi
Iron uptake	12	S. flexneri, S. boydii, S. enterica serovar Typhimurium, S. enterica serovar Typhi, other pathogenic E. coli
Resistance to organic or inorganic chemicals	7	other pathogenic E. coli, E. coli O157:H7, C. crescentus, M. loti, A. tumefaciens
Transport	11	E. coli O157:H7, other pathogenic E. coli, S. enterica serovar Typhi
Membrane	9	E. coli O157:H7, Y. pestis, K. pneumoniae, C. jejuni, S. enterica serovar Typhi
Plasmid replication and transfer functions	7	C. crescentus, other pathogenic E. coli
DNA replication and transfer functions	2	S. flexneri, S. enterica serovar Typhimurium
Cell structure	9	E. coli O157:H7, other pathogenic E. coli, S. enterica serovar Typhi, S. enterica serovar Typhimurium
Biosynthesis	8	E. coli O157:H7, other pathogenic E. coli
Central intermediary metabolism	9	S. flexneri, V. cholerae
Conserved unknown	68	S. flexneri, nonpathogenic E. coli, other pathogenic E. coli, S. enterica serovar Typhi, P. aeruginosa, X. fastidiosa, S. meliloti