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Effect of combining vaccinating proteins on immunogenicity of components. Anti-C50 and anti-D50 antibody levels in serum were measured by ELISA for mice receiving either monovalent (Mono.) or bivalent (Bival.) vaccines. The geometric mean titer of each group and the standard error are presented. ∗, the mean anti-D50 titer of the group receiving D50 as part of a bivalent vaccine was significantly less than that of the group receiving D50 as a monovalent vaccine.
