TABLE 1.
Anti-B. burgdorferi IgG and IgG isotype reciprocal endopoint ELISA titersa
| Mouse group or strain | Mean reciprocal endpoint ELISA titer
|
||||
|---|---|---|---|---|---|
| IgG | IgG1 | IgG2a | IgG2b | IgG3 | |
| Syringe inoculated | |||||
| B6.129 (WT) | 43,750 ± 6,250 | 4,800 ± 924 | 1,100 ± 300 | 14,400 ± 4,027 | 9,600 ± 1,848 |
| B6.129 (TCR δ−/−) | 42,560 ± 7,440 | 5,120 ± 784 | 1,840 ± 588 | 18,560 ± 4,571 | 1,280 ± 528b |
| BALB/c (WT) | 17,920 ± 3,135 | 2,880 ± 320 | 12,800 ± 3,505 | 5,440 ± 2,147 | 1,100 ± 392 |
| BALB/c (TCR δ−/−) | 17,920 ± 3,135 | 10,880 ± 1920c | 6,240 ± 4,843 | 5,440 ± 4,468 | 1,120 ± 196 |
| Tick infected | |||||
| BALB/c (WT) | 13,867 ± 2,569 | 10,133 ± 1,736 | 3,267 ± 1,950 | 8,000 ± 1,600 | 4,033 ± 2,673 |
| BALB/c (TCR δ−/−) | 13,867 ± 2,569 | 10,667 ± 1,349 | 5,067 ± 1,855 | 7,200 ± 1,927 | 4,000 ± 1,789 |
a
Results from a minimum of five mice/group are reported as the mean of reciprocal endpoint ELISA titers ± standard error of the mean. WT, wild type.
b
Significantly different (P = 0.0159) from value for wild-type mice as calculated by the Mann-Whitney test.
c
Significantly different (P = 0.0317) from value for wild-type mice as calculated by the Mann-Whitney test.