TABLE 2.
Absence of γδ T cells does not alter disease in B. burgdorferi-infected micea
| Expt or mouse strain + treatment | Day of infection | Results
|
||
|---|---|---|---|---|
| Carditis | Arthritis | Arthritis severity | ||
| Expt 1 | ||||
| BALB/c + UC7-13D5 | 14 | 0/10 | 11/20 | 1.1 ± 0.5 |
| BALB/c + hamster serum | 14 | 0/10 | 9/20 | 1.2 ± 0.5 |
| Expt 2 | ||||
| B6.129 (WT) | 14 | 0/6 | 3/12 | 1.4 ± 0.6 |
| B6.129 (TCR δ−/−) | 14 | 0/6 | 5/12 | 1.1 ± 0.4 |
| B6.129 (WT) | 30 | 0/6 | 4/12 | 1.2 ± 0.3 |
| B6.129 (TCR δ−/−) | 30 | 0/6 | 5/12 | 1.3 ± 0.4 |
| Expt 3 | ||||
| BALB/c (WT) | 14 | 5/5 | 12/13 | 1.0 ± 0.2 |
| BALB/c (TCR δ−/−) | 14 | 5/5 | 15/16 | 1.2 ± 0.3 |
| BALB/c (WT) | 42 | 1/5 | 3/17 | 0.6 ± 0.2 |
| BALB/c (TCR δ−/−) | 42 | 0/3 | 2/12 | 0.3 ± 0.3 |
In experiment 1, BALB/c mice were treated with the indicated agents as described in Materials and Methods and then infected by inoculation of spirochetes into both hind feet. In experiments 2 and 3, mice were infected by inoculation of spirochetes into the skin of the back. Carditis results are reported as the number of mice with acute carditis over the total number of animals examined. Arthritis presence in tibiotarsal joints was assessed and expressed as the number of inflamed joints over the total number of joints examined. Arthritis severity was determined by averaging the individual scores for the most severely affected joint in each mouse ± the standard error of the mean.