Reactivity of syphilitic serum samples to recombinant Tp0751. (A) Reactivity of sequential rabbit serum samples collected from experimentally infected rabbits. The serum samples on the x axis represent pools of serum samples collected from rabbits infected with T. pallidum for the indicated time periods. NRS, normal rabbit serum. (B) Reactivity of human serum samples from different stages of syphilis infection. The serum samples on the x axis are grouped by stages of syphilis: P, primary (n = 14); S, secondary (n = 13); L, latent (n = 8); N, neurosyphilis (n = 8). The overall mean absorbance (Abs.) of each group is represented by a horizontal line.