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Relationship between changes in bacterial density and total drug concentrations for the pharmacodynamic parameters AUC/MIC ratio (r2 = 0.8230) (a), peak/MIC (r2 = 0.6702) (b), and %T>MIC (r2 = 0.6314) (c). Each datum point represents the mean of six to eight thighs. SPN, S. pneumoniae.
