TABLE 2.
Ritonavir pharmacokinetic parameters (means ± SD) from treatment with ritonavir (600 mg every 12 h) alone and in combination with delavirdine (400 mg every 8 h)
| Drug(s) (day of assessment) | AUC0-12 (μM · h) | Cmax (μM) | Cmin (μM) | Tmax (h) |
|---|---|---|---|---|
| Ritonavir (day 7) | 94 ± 36 | 14.8 ± 6.7 | 3.6 ± 2.1 | 3.0 ± 2.5 |
| Ritonavir plus delavirdine (day 28) | 154 ± 83 | 24.6 ± 13.9 | 6.52 ± 4.85 | 2.6 ± 2.6 |
| Geometric mean ratioa (90% confidence interval) | 1.51 (1.24-1.83) | 1.54 (1.24-1.91) | 1.76 (1.5-2.05) | NDb |
a
Ratio of day 28 parameter to day 7 parameter.
b
ND, not determined.