TABLE 2.

MICs of ceftazidime alone or in combination with AM-112 against β-lactamase-producing bacteria

Organism	Group/classa	MIC (μg/ml)
		AM-112	CAZb	CAZ + AM-112 (1:1)c	CAZ + AM-112 (2:1)b
E. coli J53 SHV-1	2b/A	32	2	0.25	0.125
E. coli J53 SHV-2	2be/A	16	0.25	0.125	0.125
E. coli J53 SHV-3	2be/A	8	0.125	0.03	0.125
E. coli J53 SHV-4	2be/A	32	>64	4	8
E. coli J53 SHV-5	2be/A	32	16	8	16
E. coli J53 TEM-1	2b/A	32	0.25	0.25	0.5
E. coli J53 TEM-3	2be/A	16	16	4	2
E. coli J53 TEM-6	2be/A	32	>64	8	4
E. coli J53 TEM-9	2be/A	32	>64	8	8
E. coli J53 TEM-10	2be/A	32	>64	8	16
P. aeruginosa 1405-con	1/C	>128	>64	32	32
P. aeruginosa 2297-con	1/C	>128	>64	64	64
P. aeruginosa ATCC 27853	1/C	>128	2	4	2
E. cloacae P99	1/C	16	32	4	4
E. cloacae Hennessey	1/C	32	>64	4	4
E. cloacae 84-con	1/C	32	>64	4	4
C. freundii C2-con	1/C	32	64	0.03	2
S. marcescens S2-con	1/C	64	1	0.03	0.5
M. morganii M1-con	1/C	64	8	1	1
E. coli J53 OXA-1	2d/D	16	0.25	0.5	0.25
E. coli J53 OXA-2	2d/D	16	0.25	0.25	0.25
E. coli J53 OXA-3	—/D	32	0.5	0.5	0.5
E. coli J53 OXA-5	2d/D	32	0.5	0.25	0.25

^aGroup, Bush-Jacoby-Medeiros classification (4); class, Ambler molecular class (1). —, no group assigned.

^bMICs quoted for CAZ-AM-112 combinations refer to ceftazidime component.

^cCAZ, ceftazidime.