TABLE 1.

In vitro activities of daptomycin and comparative agents

Species, phenotype (no. of isolates tested), and antimicrobial agent	MIC range (μg/ml)	MIC90 (μg/ml)	% Susceptible (NCCLS susceptible breakpoint)
S. pneumoniae
Penicillin susceptible (728)
Penicillin	≤0.03-0.06	≤0.03	100 (≤0.06)
Amoxicillin-clavulanate	≤0.015-0.25	≤0.015	100 (≤2)
Cefuroxime	≤0.015-0.25	0.03	100 (≤1)
Ceftriaxone	≤0.12-0.5	≤0.12	100 (≤1)
Vancomycin	≤0.06-0.5	0.25	100 (≤1)
Erythromycin	≤0.015->2	0.06	93.1 (≤0.25)
Clindamycin	≤0.25->1	≤0.25	98.1 (≤0.25)
Levofloxacin	≤0.25->8	1	99.3 (≤2)
SXT	≤0.06->4	1	89.3 (≤0.5)
Quinupristin-dalfopristin	≤0.12-2	0.5	99.0 (≤1)
Linezolid	≤0.25-2	1	100 (≤2)
Daptomycin	≤0.015-0.25	0.12	(NA)a
Penicillin intermediate (248)
Penicillin	0.12-1	1	0
Amoxicillin-clavulanate	≤0.015-4	1	99.6
Cefuroxime	≤0.015-2	0.5	98.8
Ceftriaxone	≤0.12->4	4	31.0
Vancomycin	≤0.06-0.25	0.25	100
Erythromycin	0.03->2	>2	35.5
Clindamycin	≤0.25->1	>1	79.8
Levofloxacin	≤0.25->8	1	98.8
SXT	0.12->4	>4	33.9
Quinupristin-dalfopristin	≤0.12-1	0.5	100
Linezolid	≤0.25-1	1	100
Daptomycin	≤0.015-0.5	0.25
Penicillin resistant (187)
Penicillin	2->8	4	0
Amoxicillin-clavulanate	0.25-8	8	46.0
Ceftriaxone	0.25->4	4	81.8
Cefuroxime	2->4	>4	0
Vancomycin	≤0.06-0.25	0.25	100
Erythromycin	0.03->2	>2	13.9
Clindamycin	≤0.25->1	>1	74.3
Levofloxacin	≤0.25-8	1	98.4
SXT	0.25->4	>4	2.1
Quinupristin-dalfopristin	≤0.12-1	0.5	100
Linezolid	0.5-1	1	100
Daptomycin	≤0.015-0.25	0.12
S. pyogenes (484)
Penicillin	≤0.03-0.12	≤0.03	100 (≤0.12)
Amoxicillin-clavulanate	≤0.015-0.25	≤0.015	(NA)
Ceftriaxone	≤0.015-0.25	≤0.015	100 (≤0.5)
Cefuroxime	≤0.12-0.5	≤0.12	(NA)
Vancomycin	≤0.06-0.5	0.25	100 (≤1)
Erythromycin	≤0.015-<2	0.12	91.1 (≤0.25)
Clindamycin	≤0.25->1	≤0.25	98.6 (≤0.25)
Levofloxacin	≤0.25-8	0.5	99.8 (≤2)
SXT	≤0.06->4	0.25	(NA)
Quinupristin-dalfopristin	≤0.12-1	≤0.12	100 (≤1)
Linezolid	≤0.25-2	1	100 (≤2)
Daptomycin	≤0.015-0.5	0.06	(NA)
S. agalactiae (273)
Penicillin	≤0.03-0.12	0.06	100 (≤0.12)
Amoxicillin-clavulanate	≤0.015-0.12	0.06	(NA)
Ceftriaxone	≤0.015-0.12	0.06	100 (≤0.5)
Cefuroxime	≤0.12-0.5	≤0.12	(NA)
Vancomycin	0.12-0.5	0.25	100 (≤1)
Erythromycin	0.03->2	>2	72.2 (≤0.25)
Clindamycin	≤0.25->1	>1	87.5 (≤0.25)
Levofloxacin	≤0.25->8	1	98.9 (≤2)
SXT	≤0.06-4	0.12	(NA)
Quinupristin-dalfopristin	≤0.12-1	0.25	100 (≤1)
Linezolid	0.5-1	1	100 (≤2)
Daptomycin	0.03-0.5	0.25	(NA)
Viridans streptococci (369)
Penicillin	≤0.03-8	2	71.3 (≤0.12)
Amoxicillin-clauvulanate	≤0.015-16	2	(NA)
Ceftriaxone	≤0.015->4	1	87.5 (≤1)
Cefuroxime	≤0.12->4	4	(NA)
Vancomycin	≤0.06-2	0.5	99.7 (≤1)
Erythromycin	≤0.015->2	>2	51.8 (≤0.25)
Clindamycin	≤0.25->1	≤0.25	93.8 (≤0.25)
Levofloxacin	≤0.25->8	1	97.6 (≤2)
SXT	≤0.06->4	2	(NA)
Quinupristin-dalfopristin	≤0.12-2	1	99.5 (≤1)
Linezolid	≤0.25-2	1	100 (≤2)
Daptomycin	≤0.015-2	1	(NA)
S. aureus
Oxacillin susceptible (713)
Oxacillin	≤0.06-2	0.5	100 (≤2)
Vancomycin	≤0.25-1	1	100 (≤4)
Erythromycin	≤0.12-16	>16	34.6 (≤0.5)
Clindamycin	0.06->4	0.5	92.7 (≤0.5)
Gentamicin	≤0.06->16	1	97.2 (≤4)
Teicoplanin	≤0.12-16	0.5	99.9 (≤8)
Ciprofloxacin	≤0.03->8	2	89.3 (≤1)
SXT	≤0.25->4	≤0.25	96.9 (≤2)
Quinupristin-dalfopristin	≤0.06-0.5	0.25	100 (≤1)
Linezolid	0.5-4	4	100 (≤4)
Daptomycin	0.03-0.5	0.25	(NA)
Oxacillin resistant (305)
Oxacillin	4->8	>8	0
Vancomycin	≤0.25-2	1	100
Erythromycin	0.5->16	>16	2.6
Clindamycin	0.06->4	>4	36.4
Gentamicin	≤0.06->16	>16	79.3
Teicoplanin	≤0.12-4	1	100
Ciprofloxacin	0.06->8	>8	12.5
SXT	≤0.25->4	>4	87.9
Quinupristin-dalfopristin	≤0.06-1	0.5	100
Linezolid	≤0.25-4	4	100
Daptomycin	0.12-0.5	0.5
Coagulase-negative staphylococci (1,126)
Oxacillin	≤0.06->8	>8	31.6 (≤0.25)
Vancomycin	≤0.25-4	2	100 (≤4)
Erythromycin	≤0.12->16	>16	28.2 (≤0.5)
Clindamycin	≤0.03->4	>4	67.5 (≤0.5)
Gentamicin	≤0.06->16	>16	71.4 (≤4)
Teicoplanin	≤0.12->32	8	96.0 (≤8)
Ciprofloxacin	≤0.03->8	>8	53.1 (≤1)
SXT	≤0.25->4	>4	61.5 (≤2)
Quinupristin-dalfopristin	≤0.06-4	0.5	99.5 (≤1)
Linezolid	≤0.25-4	2	100 (≤4)
Daptomycin	≤0.015-2	0.5	(NA)
E. faecium
Vancomycin susceptible (147)
Vancomycin	≤0.5-4	1	100 (≤4)
Ampicillin	≤0.25-128	64	44.2 (≤8)
Teicoplanin	≤0.03-8	0.5	100 (≤8)
Ciprofloxacin	≤0.12->64	>64	32.7 (≤1)
Quinupristin-dalfopristin	≤0.12-8	2	85.7 (≤1)
Linezolid	≤0.5-2	2	100 (≤2)
Daptomycin	0.06-8	4	(NA)
Vancomycin resistant (219)
Vancomycin	32->256	>256	0
Ampicillin	0.5->128	128	0.9
Teicoplanin	≤0.03->64	>64	14.2
Ciprofloxacin	0.25->64	>64	1.4
Quinupristin-dalfopristin	0.25-2	1	97.3
Linezolid	1-4	2	99.5
Daptomycin	0.25-4	4
E. faecalis
Vancomycin susceptible (2,049)
Vancomycin	≤0.5-4	2	100 (≤4)
Ampicillin	≤0.25-8	1	100 (≤8)
Teicoplanin	≤0.03-1	0.12	100 (≤8)
Ciprofloxacin	≤0.12->64	64	59.3 (≤1)
Quinupristin-dalfopristin	≤0.12-32	8	3.9 (≤1)
Linezolid	≤0.5-2	2	100 (≤2)
Daptomycin	0.03-4	2	(NA)
Vancomycin resistant (40)
Vancomycin	32->256	>256	0
Ampicillin	≤0.25-2	2	100
Teicoplanin	≤0.03->64	>64	67.5
Ciprofloxacin	0.5->64	>64	7.5
Quinupristin-dalfopristin	≤0.12-32	16	2.5
Linezolid	1-2	2	100
Daptomycin	≤0.015-2	2
Other Enterococcus spp. (80)
Vancomycin	≤0.5-256	4	98.8 (≤4)
Ampicillin	≤0.25-128	4	93.8 (≤8)
Teicoplanin	≤0.03-16	0.25	98.8 (≤8)
Ciprofloxacin	≤0.12->64	16	75.0 (≤1)
Quinupristin-dalfopristin	0.25-32	4	47.5 (≤1)
Linezolid	1-4	2	98.8 (≤2)
Daptomycin	0.03-8	4	(NA)

^aNA, NCCLS published breakpoints unavailable for interpretation (19).