TABLE 2.

Effects of praziquantel and oxamniquine combinations for treatment of S. mansoni and S. haematobium infections among schoolchildren from Malawi and Zimbabwe^a

Study location	Parasite				Treatment (mg/kg)		Therapeutic efficacy
	S. mansoni		S. haematobium		Praziquantel	Oxamniquine	S. mansoni		S. haematobium
	No. of patients infected	Infection intensity (no. of eggs/g of stool)	No. of patients infected	Infection intensity (no. of eggs/10 ml of urine)			No. (%) of patients cured	Infection intensity (no. of eggs/g of stool [% reduction])	No. (%) of patients cured	Infection intensity (no. of eggs/10 ml of urine [% egg reduction])
Malawi	22	495			8	4	NAb	282 (43)
	24	624			10	7.5	NA	137 (78)
	26	328			15	7.5	NA	3 (99)
	30	241			20	10	NA	1 (100)
			29	135	15	7.5			NA	1 (99)
			27	270	20	10			NA	1 (100)
Zimbabwe	10	557			8	4	3 (30)	35 (94)
	30	208			15	7.5	23 (77)	8 (96)
	18	92			20	10	16 (89)	11 (88)
			10	575	8	4			0 (0)	178 (69)
			30	641	15	7.5			0 (0)	42 (93)
			18	750	20	10			0 (0)	41 (93)

^aBoth studies were designed as randomized, nonblinded, dose-ranging trials (16, 54).

^bNA, not assessed.