TABLE 4.

Effects of combination chemotherapy with praziquantel and artesunate against S. mansoni infections in a nonblinded trial in Senegal and against S. haematobium infections in a randomized, double-blind placebo-controlled clinical trial in Gabon compared to either praziquantel or artesunate monotherapy

Group and treatment (reference)	Baseline			Therapeutic efficacy
	No. of patients infected	Infection intensity pretreatmentc		No. (%) of patients cured	Infection intensity posttreatmentc
		No. of eggs/g of stool	No. of eggs/10 ml of urine		No. of eggs/g of stool	No. of eggs/10 ml urine
S. mansoni-infected patients from Senegal (20)a
Praziquantel	36	162		16 (44)	26 (84)
Artesunate	35	205		8 (23)	83 (59)
Praziquantel + artesunate	39	157		27 (69)	17 (89)
S. haematobium-infected children from Gabon (6)b
Placebo + placebo	30		22	6 (20)		8.7 (75)
Praziquantel + placebo	89		37	65 (73)		2.3 (94)
Artesunate + placebo	89		35	24 (27)		7.0 (80)
Praziquantel + artesunate	88		32	71 (81)		0.4 (99)

^aPraziquantel was administered orally at a single dose of 40 mg/kg; artesunate was administered orally at a total dose of 12 mg/kg (4 mg/kg once on day 1, followed by 2 mg/kg once a day on days 2 to 5).

^bPraziquantel was administered orally at a single dose of 40 mg/kg; artesunate was administered orally at a total dose of 12 mg/kg (4 mg/kg once a day on days 1 to 3).

^cInfection intensity is expressed as the geometric mean. The values in parentheses are percent reductions.