Figure 3. Structures of common inhibitors of glycosyl hydrolases and glycosyltransferases including ScTPase.

(A) Validoxylamine A (1.7 μM; the present study); (B) α,α-thio-trehalose (560 μM) [10]; (C) acarviosine unit of acarbose (n.a.); (D) isofagomine (56 μM) [15]; (E) 1-deoxynojirimycin (1200 μM) [15]; (F) D-glucal (320 μM) [10]. Values in parentheses show inhibition constants that describe binding of the inhibitor to the complex of ScTPase and phosphate; n.a., not applicable.