Table 3. Effect of PDHK4 deficiency on glucose metabolism by isolated diaphragm.

Diaphragms were obtained from mice starved for 48 h. Data are means±S.E.M., with n=5 in each group.

		Rate [μmol.h−1·(g wet weight)−1]
Process	Source of diaphragm…	PDHK4+/+ mice	PDHK4−/− mice
Glycolysis		20.7±2.8	13.4±0.5*
Lactate release		28.7±3.4	17.9±0.3*
Pyruvate release		2.08±0.40	0.49±0.09*
Glucose oxidation		1.13±0.10	1.54±0.11*
Net glycolysis		20.7±2.8	13.4±0.5*
Glycogen synthesis		2.40±0.17	3.28±0.58

* Significantly different from wild-type (PDHK4^+/+) mice (P<0.05).