Table 4. Effect of PDHK4 deficiency on fatty acid oxidation by isolated diaphragm.

Diaphragms were obtained from mice starved for 48 h. Fatty acid oxidation rate refers to the sum of the rate of production of CO₂ and acid-soluble radioactive products. Data are means±S.E.M., with n=3 in each group.

		Production rate [μmol of palmitate·h−1·(g wet weight)−1]
Product	Source of diaphragm…	PDHK4+/+ mice	PDHK4−/− mice
CO2		1.22±0.10	0.61±0.04*
Acid-soluble products		0.47±0.01	0.19±0.04*
Fatty acid oxidation		1.69±0.09	0.80±0.06*

* Significantly different from PDHK4^+/+ mice (P<0.002).