TABLE 1.

MBCs and LD₅₀s of hBD-3 against a reference panel of clinically relevant bacterial species

Strain	MBC (μg/ml)	LD50 (μg/ml)
Gram-positive cocci
Staphylococcus aureus ATCC 12600	1.56	0.2
Staphylococcus aureus ATCC 33593	6.25	1.56
Staphylococcus epidermidis ATCC 14990	1.56	0.39
Streptococcus pyogenes ATCC 12344	6.25	3.1
Streptococcus pneumoniae ATCC 33400	6.25	1.56
Gram-negative fermentative rods
Escherichia coli ATCC 25922	0.39	0.1
Klebsiella pneumoniae ATCC 13883	0.1	0.05
Enterobacter cloacae ATCC 13047	6.25	0.78
Serratia marcescens NCTC 10211	50	6.25
Citrobacter freundii NCTC 9750	0.39	0.2
Aeromonas hydrophila ATCC 7966	50	3.1
Gram-negative nonfermentative rods
Brevundimonas diminuta ATCC 11568	0.39	0.2
Pseudomonas aeruginosa ATCC 10145	3.1	0.78
Pseudomonas aeruginosa ATCC 39324	1.56	0.39
Pseudomonas aeruginosa ATCC 11440	3.1	0.78
Pseudomonas aeruginosa ATCC 11446	3.1	0.78
Pseudomonas fluorescens NCTC 10038	0.78	0.39
Pseudomonas putida BK 4912	6.25	1.56
Stenotrophomonas maltophilia ATCC 17666	0.78	0.39
Stenotrophomonas maltophilia ATCC 10257	1.56	0.78
Stenotrophomonas maltophilia M 140	0.78	0.2
Stenotrophomonas maltophilia M 141	3.1	0.39
Stenotrophomonas maltophilia M 142	1.56	0.39
Acinetobacter baumannii ATCC 19606	0.78	0.05
Acinetobacter genospecies 3 ATCC 19004	0.39	0.2
Acinetobacter lwoffii ATCC 15309	0.2	0.1
Acinetobacter junii ATCC 17908	0.39	0.1
Acinetobacter johnsonii ATCC 17909	0.39	0.2
Acinetobacter haemolyticus ATCC 17906	0.78	0.2
Acinetobacter calcoaceticus ATCC 23055	0.78	0.39
Acinetobacter genospecies 11 ATCC 11171	1.56	0.39
Acinetobacter genospecies 10 ATCC 17924	0.78	0.2
Burkholderia cepacia ATCC 25416	>100	>100