TABLE 3.
Relationships among the ica operon, biofilm production, and antibiotic resistancea
| Antibiotic | No. of strains positive/no. tested (%) with the following characteristics
|
OD490 (95% CI) in the microtiter plate assay for 176 strains of all species that wered:
|
|||||
|---|---|---|---|---|---|---|---|
|
ica operon presentb
|
CRA test positivec
|
||||||
| Resistant | Sensitive | Resistant | Sensitive | Resistant | Sensitive | ||
| Penicillin | 48/113 (42) | 0/7 (0) | 45/168 (27) | 0/8 (0) | 0.09 (0.06-0.11) | 0.05 (0.0-0.11) | |
| Oxacillin | 48/105 (46) | 0/15 (0) | 44/155 (28) | 1/21 (5) | 0.1 (0.07-0.22) | 0.01 (−0.02-0.05) | |
| Erythromycin | 23/52 (44) | 25/68 (37) | 11/64 (17) | 34/112 (30) | 0.07 (0.04-0.11) | 0.09 (0.07-0.13) | |
| Tetracycline | 19/33 (58) | 29/87 (33) | 13/49 (27) | 32/127 (25) | 0.05 (0.02-0.09) | 0.1 (0.07-0.13) | |
| Trimethoprim | 21/55 (38) | 27/65 (42) | 18/74 (24) | 27/102 (26) | 0.12 (0.08-0.16) | 0.07 (0.04-0.09) | |
| Gentamicin | 42/97 (43) | 6/23 (43) | 40/146 (27) | 5/30 (17) | 0.1 (0.07-0.13) | 0.03 (0.0-0.07) | |
| Netilmicin | 20/33 (61) | 28/87 (32) | 14/44 (32) | 31/132 (23) | 0.21 (0.13-0.30) | 0.05 (0.04-0.07) | |
| Amikacin | 13/23 (57) | 35/97 (36) | 8/30 (27) | 37/109 (25) | 0.23 (0.13-0.36) | 0.06 (0.04-0.08) | |
| Rifampin | 14/17 (82) | 34/103 (33) | 3/17 (18) | 42/159 (26) | 0.19 (0.1-0.3) | 0.08 (0.06-0.1) | |
| Fusidic acid | 9/20 (45) | 39/100 (39) | 4/22 (18) | 41/154 (27) | 0.13 (0.06-0.22) | 0.08 (0.06-0.1) | |
| Ciprofloxacin | 10/11 (91) | 38/109 (35) | 2/17 (12) | 43/159 (27) | 0.11 (0.03-0.23) | 0.08 (0.06-0.11) | |
a
Results shown in bold signify a P value of <0.01. The P value was calculated in a test of association between antibiotic sensitivity and the characteristic for which a result is shown.
b
S. epidemidis strains only (n = 120).
c
Strains of all species (n = 176).
d
See Table 1, footnote a.