Table 1.
Recovery of cell culture infectivity from HCVcc-infected animals
| Virus preparation | Time in vivo, weeks | Time in vitro, days | Infectivity, TCID50/ml | Specific infectivity, TCID50 per RNA |
|---|---|---|---|---|
| FL-J6/JFH (HCVcc) | n/a* | 5.7 ± 2.3 | 3.93 × 104(±2.63 × 104) | 1/1,230(±1/602) |
| Viruses present in vivo | ||||
| Chimpanzee 4×0483 | 1 | n/a | 6.26 × 102 | 1/15 |
| 3 | n/a | 1.92 × 102 | 1/50 | |
| Chimpanzee 4×0495 | 2 | n/a | 3.00 × 102 | 1/148 |
| 3 | n/a | 1.75 × 102 | 1/25 | |
| Mouse A | 3 | n/a | <10 | n/a |
| Mouse C | 3 | n/a | 6.93 × 104 | 1/9 |
| Mouse D | 20 | n/a | 5.38 × 104 | 1/18 |
| Viruses recovered in vitro | ||||
| Chimpanzee 4×0483 | 3 | 9 | 2.43 × 103 | 1/1,090 |
| Chimpanzee 4×0495 | 3 | 9 | 7.94 × 103 | 1/1,260 |
| Mouse D | 20 | 5 | 5.38 × 105 | 1/472 |
n/a, not applicable.
*Average values from seven independent stocks of HCVcc (±SD).