Table 1.

Effects of finasteride treatment and withdrawal on ethanol intake and bout microarchitecture. VEH Control values represent the collapsed mean ± SEM across all treatment phases for n = 8 VEH-treated mice. All other value represent the mean ± SEM of each treatment phase for n = 16 FIN-treated mice.

	Treatment Phase
	VEH Control	Baseline	Acute Treatment	Chronic Treatment	Early Withdrawal	Protracted Withdrawal
General Measures
10E Dose (g/kg)	3.09 ± 0.09	3.00 ± 0.17	2.41 ± 0.19^***	2.84 ± 0.13	2.40 ± 0.18^***	3.00 ± 0.17
10E Licks	1090 ± 63	1151 ± 62	950 ± 69^***	1073 ± 43	906 ± 66^***	1092 ± 63
Water Licks	97 ± 38	116 ± 30	175 ± 41^*	105 ± 26	102 ± 30	104 ± 43
Total Fluid Intake (ml)	1.09 ± 0.09	1.10 ± 0.05	0.96 ± 0.05^**	1.06 ± 0.04	0.93 ± 0.06^***	1.12 ± 0.05
Preference Ratio	.96 ± .02	.96 ± .01	.87 ± .05^***	.95 ± .02	.93 ± .02	.94 ± .03
Body Weights (g)	26.2 ± 0.3	27.9 ± 0.6	28.0 ± 0.6	27.8 ± 0.6	27.8 ± 0.6	27.9 ± 0.5

Total Session 10E Bout Dynamics
Bout Frequency	11.5 ± 1.0	10.6 ± 0.7	10.9 ± 0.8	11.3 ± 0.5	9.2 ± 1.0^*	9.7 ± 0.6
Bout Size (licks)	100 ± 5	115 ± 7	84 ± 5^***	98 ± 5^*	108 ± 9	116 ± 7
Inter-bout Interval (min)	11.7 ± 1.4	12.2 ± 1.2	13.0 ± 2.8	10.5 ± 0.6	16.8 ± 2.2^*	13.9 ± 1.3
Bout Length (min)	0.90 ± 0.10	1.04 ± 0.09	0.68 ± 0.08^***	0.70 ± 0.07^***	0.74 ± 0.08^***	0.94 ± 0.10
Lick Rate (licks/min)	316 ± 21	296 ± 20	343 ± 22^*	354 ± 21^**	344 ± 22^*	320 ± 19

First 10E Bout Dynamics
Latency to 1^st Bout (min)	1.16 ± 0.36	1.37 ± 0.27	4.36 ± 1.52^*	1.89 ± 0.66	2.30 ± 1.01	1.24 ± 0.20
Size of 1^st Bout (licks)	212 ± 28	177 ± 25	118 ± 19^*	170 ± 22	180 ± 26	224 ± 31
Length of 1^st Bout (min)	2.22 ± 0.20	1.92 ± 0.27	1.54 ± 0.38	1.90 ± 0.32	1.76 ± 0.28	2.43 ± 0.38
Rate of 1^st Bout (licks/min)	152 ± 13	183 ± 32	200 ± 43	155 ± 23	164 ± 28	152 ± 31

p ≤ .05,

^**

p < .01

^***

p < .001 versus within-group Baseline values for FIN-treated mice.