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. 2006 Aug 8;103(33):12505–12510. doi: 10.1073/pnas.0605207103

Fig. 2.

Fig. 2.

Evidence for operation of the GABA shunt of the TCA cycle in prostate NE cancer cells. (A) Overview of shunt. α-Ketoglutarate is converted to glutamate by glutamate dehydrogenase (GDH), which is converted to GABA by glutamic acid decarboxylase 1 (GAD1). GABA transaminase (GABAT) produces succinic semialdehyde and glutamate from GABA and α-ketoglutarate (α-KG), which is then converted to succinate and NADH by succinic semialdehyde dehydrogenase (SSADH). (B) Biochemical assays of GABA shunt components. Bracketed asterisks refer to statistically significant differences between PNEC versus LNCaP cell lines, PNEC versus LNCaP tumor xenografts, or between CR2-TAg prostate NE tumors versus normal prostates (∗, P < 0.05; ∗∗, P < 0.005; ∗∗∗, P < 0.0005).