TABLE 1.
Patient no. | Age (yr) | Disease | Donor | Immunosuppression | Day of engraftment | Antiviral treatment for prophylaxis or preemptive CMV therapy |
---|---|---|---|---|---|---|
1 | 26 | SAA | MUD | ATG, CsA, MMF, prednisolone | 17 | days 0-30 ACV; from day 25, FC, GCV, GCV + FC |
2 | 40 | MDS | MFD | TGM, CsA | 9 | days 0-30 ACV; from day 30, GCV, GCV + FC |
3 | 48 | CML | 2AgMM-FDb | None | 14 | days 0-30 ACV; from day 14, FC, GCV, GCV + FC |
4 | 34 | ALL | MUD | ATG, CsA, MMF, prednisolone | 12 | days 0-30 ACV; from day 52, FC, FC + GCV, cidofovir |
5 | 24 | ALL | MUD | ATG, CsA | 11 | days 0-30 ACV |
6 | 31 | ALL | MUD | ATG, CsA, MMF, prednisolone | 11 | days 0-30 ACV, from day 34, GCV, FC |
7 | 34 | AML | MUD | ATG, CsA, MMF, prednisolone | 11 | days 0-30 ACV |
8 | 37 | AML | 1AgMM-DUb | ATG, CsA, OKT3 | 10c | days 0-30 ACV |
9 | 54 | MM | MUD | ATG, CsA, OKT3 | 28 | days 0-30 ACV, from day 19, GCV |
Abbreviations: SAA, severe aplastic anemia; MDS, myelodysplastic syndrome; CML, chronic myeloid leukemia; ALL, acute lymphoblastic leukemia; AML, acute myeloid leukemia; MM, multiple myeloma; MUD, matched unrelated donor; 2AgMM-FD, family donor with two antigen mismatches; 1AgMM-DU, unrelated donor with one antigen mismatch; ATG, antithymocyte globulin; CsA, cyclosporine; MMF, mycofenolate mofetil; ACV, acyclovir; FC, foscarnet; GCV, ganciclovir.
Both patients received T-cell-depleted grafts.
Primary graft failure with a second graft at day 34; engraftment was at day 10 after the second transplantation.