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. 2006 Jul 5;3:54. doi: 10.1186/1743-422X-3-54

Table 6.

T-cell responses for subjects grouped by HSV-1/HSV-2 serostatus. Data is the same as Table 2 but subjects have been organized into groups based on their HSV-1 and HSV-2 serostatus. For CD4 responses, the total number of ELISPOTs (E#) for each peptide pool of that group is included. Total number of CD4 ELISPOTs for each protein from each group were used to generate a ratio of the ELISPOTs measured in HSV-1/HSV-2 double positives and HSV-2 single positives. Values were adjusted to compensate for the different number of subjects per group

HSV-2 SINGLE POSITIVIES
CD4 Responses CD8 Responses

Patient ICP27 ICP22 ICP0–1 ICP0–2 ICP0–3 ICP4–1 ICP4–2 ICP4–3 ICP4–4 ICP4–5 ICP4–6 VP22 gD ICP0 ICP4 VP22

6 W W S W W W S S
8 W S W W W W P
9 W S W S S W W P P
11 W W W W S S
12 S S W W W S S S
14 S P
15 W S W W W S S P
16 W S W S
E# 37 87 133 62 21 14 18 135 62 69 8 309 394

HSV-2/HSV-1 DOUBLE POSITIVES

CD4 Responses CD8 Responses

Patient ICP27 ICP22 ICP0–1 ICP0–2 ICP0–3 ICP4–1 ICP4–2 ICP4–3 ICP4–4 ICP4–5 ICP4–6 VP22 gD ICP0 ICP4 VP22

1 S S W W W W S W
2 W S S W S P
3 W S S S S S S P
5 W W S W S P P
13 S S S
18 W S W W S S S W P
E# 64 45 23 96 96 0 9 128 96 109 64 261 254

HSV-1 SINGLE POSITIVES

CD4 Responses CD8 Responses

Patient ICP27 ICP22 ICP0–1 ICP0–2 ICP0–3 ICP4–1 ICP4–2 ICP4–3 ICP4–4 ICP4–5 ICP4–6 VP22 gD ICP0 ICP4 VP22

7 S W
10 W S
17 S S
7 152 130
ICP27 ICP22 ICP0 ICP4 VP22 gD
2.4 0.68 1.3 1.5 1.1 0.86 Ratio of double positive/HSV-2 single positive