Table 4.

Mean CS in mouse, in paralogues and K_A/K_S values for dominant and recessive disease genes by GO slim category

	CS mouse
	nD	Disease	Disease dominant	Disease recessive
Enzyme regulation	0.778	0.790	0.818	0.755
Transcription regulation	0.800	0.860	0.871	0.824
Nucleic acid binding	0.795	0.835	0.851	0.803
Catalysis	0.809	0.819	0.832	0.815
Signal transduction	0.751	0.748	0.776	0.708
Structural molecule	0.828	0.831	0.838	0.815
Transporter	0.824	0.848	0.862	0.841
Carrier	0.838	0.881	0.884	0.880
	CS paralogues
	nD	Disease	Disease dominant	Disease recessive
Enzyme regulation	0.374	0.272	0.300	0.236
Transcription regulation	0.353	0.422	0.440	0.359
Nucleic acid binding	0.358	0.370	0.431	0.250
Catalysis	0.381	0.355	0.430	0.331
Signal transduction	0.383	0.347	0.406	0.261
Structural molecule	0.449	0.482	0.595	0.207
Transporter	0.424	0.400	0.539	0.331
Carrier	0.425	0.432	0.571	0.402
	KA/KS chimpazee
	nD	Disease	Disease dominant	Disease recessive
Enzyme regulation	0.163	0.233	0.223	0.251
Transcription regulation	0.170	0.144	0.109	0.253
Nucleic acid binding	0.188	0.164	0.149	0.190
Catalysis	0.185	0.179	0.150	0.189
Signal transduction	0.213	0.173	0.138	0.238
Structural molecule	0.201	0.183	0.155	0.250
Transporter	0.176	0.166	0.082	0.213
Carrier	0.170	0.197	0.123	0.213