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Effect of 27 μM simvastatin, 100 μM mevastatin and 50 μM lovastatin on lactacystin plus TPA induced 6-keto-PGF1α production after 6 h incubation. At the levels tested, simvastatin, mevastatin and lovastatin alone do significantly stimulate basal PGI2 production, but by < 1 ng/ml. The analyses were performed on triplicate dishes. * Statistically significant vs lactacystin plus TPA (P < 0.05). This experiment was repeated with similar results.
