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Importance of choice of "breakpoints" on "spline function" deconvolution. Comparison of intestinal absorption rate determined by the "spline function" deconvolution method (black line) with the PBPK model input (red line) for one set of "noisy" data. The two columns correspond to different sets of B-spline "breakpoints" and the rows are for different value of the spline deconvolution smoothing parameter.
