Table 1.

Properties of Na⁺ channels

Measurement	Control	Salt-loaded	P
Cell capacitance, pF	16.2  ±  0.4	21.5  ±  0.8	<0.001
Transient current
Peak amplitude, nA	15.8  ±  1.1	25.3  ±  2.1	<0.001
Density, pA/pF	989 ± 70	1206 ± 95	0.09
	n = 44	n = 45
V1/2 activation, mV	−28.5  ±  1.4	−34.4  ±  1.2	<0.005
V1/2 inactivation, mV	−62.9  ±  1.3	−68.6  ±  1.4	<0.01
	n = 17	n = 17
Inactivation kinetics
Recovery at  −80 mV, ms	13.6  ±  0.7	19.6  ±  1.7	<0.005
Development at  −80 mV, ms	28.8  ±  2.2	37.7  ±  3.6	<0.05
	n = 33	n = 30
Ramp current
Amplitude, pA	190.3  ±  17	396.2  ±  50	<0.001
Density, pA/pF	12.0  ±  1.0	19.5  ±  2.3	<0.005
	n = 34	n = 29