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. 1984 Jun;56(3):645–652.

Total and specific IgG4 antibody levels in atopic eczema.

J Merrett, R S Barnetson, M L Burr, T G Merrett
PMCID: PMC1535979  PMID: 6744664

Abstract

Total IgG4 and IgG4 antibody levels specific for 10 allergens (three inhaled and seven ingested) were measured by radioimmunoassay of sera taken from three groups of adult patients: (1) 32 cases of atopic eczema, (2) 28 cases of respiratory allergy and (3) 156 normal volunteers. In all three groups IgG4 antibody activity was mainly directed against common foods, and generally the group with atopic eczema had higher total and specific IgG4 levels than the cases of respiratory allergy, who in turn had higher titres than the normal group. There was within each group a tendency for men to have more total IgG4 than women and the difference was statistically significant among the normals. There was evidence of an IgG4 restricted response in atopic eczema because despite the group's elevated total IgG4 its total IgG4 remained within normal limits. Furthermore specific IgG4 was correlated with the corresponding specific IgE level in five of the 10 allergens examined. These results are generally consistent with the view that IgG4 levels are raised in cases of atopic eczema due to prolonged exposure to an allergen which initiated an IgE response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aalberse R. C., van der Gaag R., van Leeuwen J. Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. J Immunol. 1983 Feb;130(2):722–726. [PubMed] [Google Scholar]
  2. Barnetson R. S., Merrett T. G. Food allergy and atopic eczema. Proc Nutr Soc. 1983 Jun;42(2):247–256. doi: 10.1079/pns19830029. [DOI] [PubMed] [Google Scholar]
  3. Burr M. L., St Leger A. S., Bevan C., Merrett T. G. A community survey of asthmatic characteristics. Thorax. 1975 Dec;30(6):663–668. doi: 10.1136/thx.30.6.663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Clendenning W. E., Clack W. E., Ogawa M., Ishizaka K. Serum IgE studies in atopic dermatitis. J Invest Dermatol. 1973 Oct;61(4):233–236. doi: 10.1111/1523-1747.ep12676481. [DOI] [PubMed] [Google Scholar]
  5. GREENWOOD F. C., HUNTER W. M., GLOVER J. S. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem J. 1963 Oct;89:114–123. doi: 10.1042/bj0890114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. John A. C., Merrett T. G. The radioallergosorbent test (RAST) in nasal polyposis. J Laryngol Otol. 1979 Sep;93(9):889–898. doi: 10.1017/s0022215100087855. [DOI] [PubMed] [Google Scholar]
  7. Juhlin L., Johansson G. O., Bennich H., Högman C., Thyresson N. Immunoglobulin E in dermatoses. Levels in atopic dermatitis and urticaria. Arch Dermatol. 1969 Jul;100(1):12–16. doi: 10.1001/archderm.100.1.12. [DOI] [PubMed] [Google Scholar]
  8. Lee T. H., Durham S. R., Merrett J., Merrett T. G., Kay A. B. Allergen-specific IgG-4 in bronchial asthma. Lancet. 1982 Nov 6;2(8306):1048–1049. doi: 10.1016/s0140-6736(82)90084-8. [DOI] [PubMed] [Google Scholar]
  9. Leung D. Y., Rhodes A. R., Geha R. S. Enumeration of T cell subsets in atopic dermatitis using monoclonal antibodies. J Allergy Clin Immunol. 1981 Jun;67(6):450–455. doi: 10.1016/0091-6749(81)90098-1. [DOI] [PubMed] [Google Scholar]
  10. Merrett J., Burr M. L., Merrett T. G. A community survey of IgG4 antibody levels. Clin Allergy. 1983 Sep;13(5):397–407. doi: 10.1111/j.1365-2222.1983.tb02615.x. [DOI] [PubMed] [Google Scholar]
  11. Merrett T. G., Burr M. L., Saint Leger A. S., Merrett J. Circulating IgE levels in the over-seventies. Clin Allergy. 1980 Jul;10(4):433–439. doi: 10.1111/j.1365-2222.1980.tb02126.x. [DOI] [PubMed] [Google Scholar]
  12. Merrett T. G., Merrett J. Methods of quantifying circulating IgE. Clin Allergy. 1978 Nov;8(6):543–557. doi: 10.1111/j.1365-2222.1978.tb01508.x. [DOI] [PubMed] [Google Scholar]
  13. Platts-Mills T. A., von Maur R. K., Ishizaka K., Norman P. S., Lichtenstein L. M. IgA and IgG anti-ragweed antibodies in nasal secretions. Quantitative measurements of antibodies and correlation with inhibition of histamine release. J Clin Invest. 1976 Apr;57(4):1041–1050. doi: 10.1172/JCI108346. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Shakib F., McLaughlan P., Stanworth D. R., Smith E., Fairburn E. Elevated serum IgE and IgG4 in patients with atopic dermatitis. Br J Dermatol. 1977 Jul;97(1):59–63. doi: 10.1111/j.1365-2133.1977.tb15428.x. [DOI] [PubMed] [Google Scholar]
  15. Strannegård I. L. Lymphocyte stimulation with phorbol myristate acetate in atopic and non-atopic individuals. Int Arch Allergy Appl Immunol. 1979;58(2):175–181. doi: 10.1159/000232190. [DOI] [PubMed] [Google Scholar]

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